PDRN (polydeoxyribonucleotide) is a DNA-derived ingredient widely discussed for skin repair. Research suggests it may support recovery by modulating inflammation (often linked to adenosine A2A signaling) and supplying nucleotides that cells can reuse during regeneration, which may promote fibroblast activity, angiogenesis, and extracellular-matrix remodeling. Evidence is strongest in medical or procedure-related repair settings, while topical cosmetic benefits depend heavily on formulation and skin penetration; overall, PDRN is best positioned for barrier support and post-procedure recovery claims with careful, evidence-aligned wording.